Lymphoproliferative skin lesion as a previously unreported adverse event detected in a patient receiving mSTR TB treatment

  • Hakob Atshemyan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,
  • Naira Khachatryan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,
  • Artak Manukyan National Center for Pulmonology, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204
  • Anush Khachatryan National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204
  • Alvard Poghosyan Haematology Center after prof. R. Yeolyan MoH RA, Armenia, Yerevan, H Nersisyan str. 7, PIN code: 0014,
DOI: https://doi.org/10.53411/jpadr.2022.3.2.7
Keywords: adverse event, lymphoproliferative skin lesion, rifampicin resistant tuberculosis, mSTR treatment

Abstract

Case Presentation: This case report presents an unreported adverse event detected when conducting pharmacovigilance activity among the patients’ cohort receiving short, modified, all-oral treatment regimens (mSTR) for rifampicin-resistant tuberculosis (TB). Lymphoproliferative skin lesion was diagnosed histologically.

Results: The withdrawal clinical response and re-challenge positive test were detected, and the causal relationship was defined as “probable”.

 

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Author Biographies

Hakob Atshemyan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,

mSTR Study Doctor,

Naira Khachatryan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204,

Deputy Director for Tuberculosis Control Programs,

Artak Manukyan, National Center for Pulmonology, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204

Director of the National Center for Pulmonology.

Anush Khachatryan, National Pulmonology Center, Armenia, Kotayk region, Abovyan city, Arzni highway, Building 10, PIN code: 2204

Head of Data Management and Monitoring.

Alvard Poghosyan, Haematology Center after prof. R. Yeolyan MoH RA, Armenia, Yerevan, H Nersisyan str. 7, PIN code: 0014,

Pathologist.

References

Margo, C. M., Crowson. A. N. (1996). Drug-induced immune dysregulation as a cause of atypical cutaneous lymphoid infiltrates: A hypothesis. Human Pathology, 27(2), 125-132.

Novice, T., Ahn, J. W., Wilcox, R., Tejasvi, T., Hristov, A., & Mancuso, J. (2020). Distinguishing reactive inflammatory dermatoses from lymphoma: 2 cases of severe drug reactions to phenytoin/phenobarbital and rosuvastatin mimicking lymphoma. JAAD case reports, 6(4), 311–315.

WHO. 2013. The use of the WHO-UMC system for standardised case causality assessment. WHO Publications, 1-3. Retrieved from: https://www.who.int/publications/m/item/WHO-causality-assessment

Published
2022-06-01
How to Cite
1.
Atshemyan H, Khachatryan N, Manukyan A, Khachatryan A, Poghosyan A. Lymphoproliferative skin lesion as a previously unreported adverse event detected in a patient receiving mSTR TB treatment. jpadr [Internet]. 2022Jun.1 [cited 2025Oct.2];3(2):34-7. Available from: https://www.jpadr.com/index.php/jpadr/article/view/77
Issue
Vol 3 No 2 (2022): Journal of Pharmacovigilance and Drug Research
Section
Case reports

Copyright (c) 2022 Hakob Atshemyan, Naira Khachatryan, Artak Manukyan, Anush Khachatryan, Alvard Poghosyan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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